Demo #36  ·  Live Interactive

The Staffing Firm
New Client Machine

Build targeted employer lists, enrich with open job signals, and send AI-personalized cold email to HR Directors and Operations Managers — generating new staffing client contracts on autopilot.

Runs on Apollo · Saleshandy · n8n · OpenAI · LinkedIn. No SDRs. No manual list building. Just booked discovery calls.

$6.20 avg cost per qualified employer intro
12% reply rate on cold email sequences
3–5 days setup to first sends
500+ employer records built per lane
$6.20
Cost per qualified intro
12%
Cold email reply rate
55%+
Open rate (warmed domains)
91%
Meeting show-up rate
01
Outreach Lane Configuration

Every staffing engagement runs across defined outreach lanes

Each lane targets a specific employer segment — industry, geography, job function, and hiring signal. We build 2 to 4 lanes simultaneously, each with its own Apollo filter set, email sequence, and LinkedIn targeting rules.

Apollo.io — New Search — Manufacturing HR Directors, 50–2,500 employees
Apollo Filters
Industry: Manufacturing, Industrial, Steel/Metals
Headcount: 50 – 2,500 employees
Title: HR Director, VP HR, Operations Manager, Plant Manager
Geography: Mississippi, Alabama, Tennessee
Hiring Signal: 3+ open roles on LinkedIn in last 30 days
Lane Targets
Total prospects found: 583
Email verified: 512 (87.8%)
Active job postings matched: 341
Currently staffing agency: Unknown (enrich)
Lane status: ● Active sending
ContactCompanyIndustryOpen RolesOutreach Status
Sandra Pruitt
HR Director
Columbus Steel Partners
Columbus, MS
Steel / Metals7  Replied — Interested
Marcus Webb
VP Human Resources
Barton Industries
Decatur, AL
Automotive Parts11  In sequence (Email 2)
Deb Fontenot
Plant Manager
Southern Packaging Co.
Tupelo, MS
Packaging / Mfg4  In sequence (Email 1)
Kevin Tran
Operations Director
Huntsville Aerospace MRO
Huntsville, AL
Aerospace / Defense9  Meeting booked
Rhea Castillo
HR Manager
Mississippi River Metals
Vicksburg, MS
Steel / Metals5  Queued — pending send
Apollo Filters
Industry: Defense, Aerospace, Gov Contracting
CAGE Code: Active DoD contractors (SAM.gov)
Title: HR Director, Talent Acquisition Lead, Program Manager
Geography: Gulf Coast, Southeast US
Hiring Signal: Active DoD contract + open TS/SCI roles
Lane Targets
Total prospects found: 218
Email verified: 189 (86.7%)
Active contract signals: 142
LinkedIn outreach (sniper): Enabled
Lane status: ● Warming — launching next week
ContactCompanyContract TypeOpen RolesOutreach Status
Col. (Ret.) Brian Marsh
VP Talent Acquisition
Hadrian Systems LLC
Pascagoula, MS
Navy / MRO14  Queued — domain warming
Alicia Drummond
HR Director
Gulf Defense Systems
Mobile, AL
Aerospace / DoD8  Queued — domain warming
James Okafor
Program Director
Barton Logistics Federal
Huntsville, AL
Army Sustainment6  Queued — domain warming
Apollo Filters
Industry: Logistics, 3PL, Warehousing, Distribution
Headcount: 100 – 5,000 employees
Title: VP Operations, Director Logistics, HR Manager
Geography: Southeast US, I-20 / I-59 corridor
Hiring Signal: Forklift / warehouse associate openings
Lane Targets
Total prospects found: 394
Email verified: 351 (89.1%)
Active warehouse postings: 287
On-deck status: Bucket B — building now
Lane status: ● On-deck (Bucket B)
Bucket B — On-Deck: This lane is built and ready. It launches after Bucket A (Manufacturing) generates enough replies to consume current capacity. Sequence is written, domains purchased, lists verified.
Apollo Filters
Industry: Hospitals, Clinics, Healthcare Staffing
Headcount: 50 – 2,000 employees
Title: CNO, HR Director, Staffing Manager, DON
Geography: Mississippi, Alabama, Tennessee
Hiring Signal: RN / LPN / CNA openings > 5 in 30 days
Lane Targets
Total prospects found: 267
Email verified: 231 (86.5%)
Active nursing openings: 194
On-deck status: Bucket B — building now
Lane status: ● On-deck (Bucket B)
Healthcare Staffing lane requires MSA negotiation expertise and compliance with state licensing requirements for placed nurses. Sequence copy and value prop is calibrated specifically for CNOs and DONs, not generic HR directors.
02
Email Sequence

4-touch AI-personalized sequence. Every email references an open role at that specific employer.

Each email is written by OpenAI using the prospect's job title, company name, industry, and active job postings as context. The first line is unique to every recipient. Sent from warmed dedicated domains on Saleshandy.

Day 1
AI-Personalized Cold Email
Open: 55.4%
Day 4
Case Study Follow-Up
Reply +4.2%
Day 8
Pain-Point Direct Ask
Reply +3.1%
Day 14
Break-Up + Calendar Link
Reply +2.8%
Email Preview — Sandra Pruitt, HR Director — Columbus Steel Partners, Columbus MS
From: jason@steelworkforce.com  ·  To: spruitt@columbussteel.com
Subject: Staffing for your 7 open production roles

Hi Sandra,

Noticed Columbus Steel Partners has 7 production and quality control roles open right now — that's a meaningful hiring push for a facility your size.

We're a staffing firm that specializes in placing skilled manufacturing workers across Mississippi and Alabama. We've filled positions for steel and metals facilities in Columbus and Decatur, typically with 3–5 qualified candidates submitted within 72 hours of a job order.

Would it be worth a 15-minute call this week to see if we're a fit for any of those open roles?

— Jason

03
Live Pipeline

Replies route automatically to GoHighLevel. Every employer is tracked from first touch to signed contract.

GoHighLevel AI classifies every reply in under 2 seconds — interested, question, opt-out. Interested replies trigger a calendar booking link. Meeting confirmations fire automatically. Show-up rate: 91%.

Sequences Active 512
Columbus Steel Partners
Sandra Pruitt — HR Dir.
Email 1 sent · Day 1
Barton Industries
Marcus Webb — VP HR
Email 2 sent · Day 4
Southern Packaging Co.
Deb Fontenot — Plant Mgr
Email 1 sent · Day 1
Replied — Interested 61
Huntsville Aero MRO
Kevin Tran — Ops Dir.
Reply: "Let's connect"
Gulf Fabricators LLC
Pat Nguyen — HR Mgr
Reply: "What industries?"
Meeting Booked 29
TenCate Protective
Maria Espinoza — TA Lead
Thu 2:00 PM — Zoom
Blount Fine Foods
Todd Hansen — COO
Fri 11:00 AM — Phone
Discovery Complete 18
Redwood Logistics
Alicia Drum — HR Dir.
Req: 12 forklift ops
Columbus Industrial
James Moore — VP Ops
Req: 5 welders, 3 QC
Contract Signed 7
Huntsville Aero MRO
Kevin Tran — Ops Dir.
● MSA executed
Southern Steel Group
Bill Yates — HR VP
● First placement live
04
How It Works

From Apollo search to signed MSA — every step automated

Step 01

Employer list built by lane in Apollo

Each outreach lane is defined by industry, headcount, geography, title, and hiring signal. Apollo filters return verified prospect records — name, title, company, email, LinkedIn URL — for every matching employer contact.

ApolloLinkedIn Sales Nav
Step 02

Open job signals enriched per prospect

Each employer's current open roles are pulled from LinkedIn Jobs or a job board API and attached to their record. OpenAI uses the job titles and count to write a unique, role-specific first line for every cold email — not a template variable swap.

LinkedIn Jobs APIOpenAI GPT-4on8n
Step 03

Email verified — under 2% bounce rate

Every email address is verified for deliverability via Hunter.io before being queued. Unverifiable contacts are flagged for LinkedIn or phone outreach instead. Bounce rate stays under 2%, protecting sender domain reputation throughout the campaign.

Hunter.ion8n
Step 04

4-email sequence launched on warmed domains

Personalized sequences load into Saleshandy and begin sending from dedicated warmed sending domains — separate from the firm's primary domain. Rotating sender accounts keep daily volumes safe. Open rates consistently 50%+.

SaleshandyGoogle WorkspaceInboxKit
Step 05

LinkedIn sniper outreach runs in parallel

For high-priority targets — VP and Director level, defense contractors, named accounts — a LinkedIn connection request and follow-up message fires in parallel with the email sequence. Connection rate: 30–45%.

LinkedInSales Navigator
Step 06

Replies classified and meetings booked automatically

GoHighLevel AI reads every reply in under 2 seconds. Interested replies trigger a calendar booking link. Sequences auto-pause for active conversations. Meetings fire with confirmation and 24hr / 1hr reminders. Show-up rate: 91%.

GoHighLevelGoogle Calendar
Step 07

Discovery → job order → placement → MSA

Post-meeting, the employer enters the GoHighLevel pipeline — Discovery, Proposal Sent, First Job Order, Placement Made, MSA Signed. Every stage is tracked with automated follow-up for stalled opportunities. Average days to first placement: 18.

GoHighLevel CRMn8n
05
ROI Model

What the numbers actually look like at scale

Based on a 500-record manufacturing lane, 4-email sequence, 30-day window.

500
Employer records in Bucket A lane
HR directors and operations managers at 50–2,500 employee manufacturers
60
Total replies (12% reply rate)
Mix of interested, questions, and opt-outs across 4-touch sequence
35
Interested replies (58% of total)
Contacts who express willingness to have a conversation
25
Discovery calls booked (72% connect)
Calendar bookings made via automated GHL booking link
8
Clients signed (32% close rate)
First job order or MSA executed within 60 days of discovery call
$6.20
Avg cost per qualified employer intro
Total platform cost ÷ 35 interested replies. Vs. $250–$400 via paid ads.
06
Stack

Every tool in this system has a specific job

No platform is chosen by default. Every tool is selected because it's the best option for its specific role in the workflow.

About This System
AI-Powered Patient Recruitment via Physician Referral — Clinical Trial Site Outreach System
This system identifies every physician in the relevant therapeutic area within driving distance of a clinical trial site, verifies their professional contact information, and deploys a coordinated multichannel outreach sequence across cold email, LinkedIn, and physical postcards to generate physician referrals directly into the enrollment pipeline. Built for clinical research sites, SMOs, and contract research organizations running active patient enrollment where physician referral is the highest-trust but most underutilized recruitment channel. According to CISCRP, 64% of patients prefer to learn about trials from their own physician — yet only 0.2% are actually recruited that way.
System Facts
CategoryDetail
Outcome DeliveredPhysician referrals routed into the enrollment pipeline, with each qualified patient record written to the CTMS automatically via API
Who BenefitsClinical research sites, SMOs, CROs, and sponsors running active patient enrollment across any therapeutic area
Target AudiencePhysicians within a defined radius of the trial site who treat patients matching the study's inclusion criteria — identified by NPI taxonomy code
Why This Channel Is UnderusedNo centralized way to reach every relevant physician at scale. Most sites rely on informal PI networks and existing relationships — missing the majority of nearby prescribers.
How Physicians Are IdentifiedCMS NPPES NPI Registry queried by taxonomy code (e.g., 207RE0101X for Endocrinology), geocoded against site coordinates by radius
Outreach ChannelsCold email (Saleshandy, 5 to 12% reply rate), LinkedIn connection plus message (30 to 45% connect rate), physical postcard to practice address (12 to 18% response rate)
Tools InvolvedCMS NPPES API, Google Maps API, Hunter.io, Saleshandy, LinkedIn, n8n, PostGrid or Lob
CTMS IntegrationRealTime eClinical, CRIO, Veeva SiteVault, Clinical Conductor — qualified referrals create patient records via API with zero coordinator data entry
Sources & Research
Frequently Asked Questions

The CMS NPPES NPI Registry assigns each licensed US physician a taxonomy code that identifies their specialty. For a diabetes or obesity trial, taxonomy code 207RE0101X (Endocrinology) and 207RB0002X (Obesity Medicine) return all endocrinologists and obesity medicine specialists in a geographic area. The NPPES API is queried with the relevant taxonomy codes and the site's geocoordinates to return all matching physicians within a configured radius — typically 15 to 30 miles. The output is a complete list of every relevant specialist near the site, from a publicly available authoritative federal database, for free.

Cold email sequences targeting physicians by specialty and therapeutic area achieve 5 to 12% reply rates for clinical trial outreach — higher than generic B2B cold email because relevance is high. LinkedIn connection requests to physicians with clinical research context achieve 30 to 45% acceptance rates. Physical postcards to practice addresses achieve 12 to 18% response rates per USPS data for healthcare professionals. Running all three channels from a single physician record maximizes reach without requiring multiple separate campaigns.

When a physician replies with a patient referral, an AI layer reviews the patient details against the study's inclusion and exclusion criteria before the coordinator sees the message. Patients who clearly do not qualify are flagged automatically. Patients who may qualify are routed to the coordinator with a pre-screening summary. Qualified referrals write directly to the CTMS via API, creating the patient record with referral source, pre-screening status, and referring physician contact all logged automatically.

Pre-built integrations exist for RealTime eClinical, CRIO, Veeva SiteVault, and Clinical Conductor. All integrations create the patient record via API — zero coordinator data entry. Custom integrations are available for proprietary CTMS platforms used by academic medical centers and large SMO networks.

Hunter.io uses email pattern discovery, MX record lookup, and SMTP verification to confirm whether a professional email address exists and will deliver. For physician outreach, Hunter is queried with the physician's name and practice domain and returns a confidence score. Addresses with 85% or higher confidence are queued for outreach. This keeps bounce rate under 2%, protecting sender domain reputation and maintaining inbox placement rates throughout the campaign.

The cost per enrolled patient via physician referral outreach varies by therapeutic area, site geography, and protocol complexity. In general, physician referral campaigns cost $200 to $800 per enrolled patient in direct platform and outreach costs — significantly less than paid media recruitment ($1,500 to $5,000 per enrolled patient) and comparable to or better than patient database outreach. The quality of physician-referred patients is also higher — they have been pre-qualified by a physician who knows their medical history and the study criteria.

Yes. The system supports multiple active studies per site simultaneously, with each study having its own physician target list (based on its specific therapeutic area and inclusion criteria), its own outreach sequence, and its own referral routing and CTMS integration. Studies do not cross-contaminate each other's physician pools or referral tracking. A site running a diabetes study and an oncology study simultaneously manages both campaigns independently from the same n8n workflow infrastructure.

How It Works
STEP 01

Study opens and therapeutic area defined

Therapeutic area, inclusion and exclusion criteria, and site coordinates entered manually or pulled from CTMS via API. Relevant NPI taxonomy codes identified for the indication.

STEP 02

NPPES registry queried for all nearby specialists

CMS NPPES API returns every physician matching the therapeutic area taxonomy codes within the configured radius of the site. Typically 50 to 500 physicians per site depending on market size and specialty.

STEP 03

Google Maps radius filter applied to narrow list

Practice addresses geocoded. Only physicians within the defined drive-time radius pass through to outreach. Approximately 30 to 60% of raw NPPES results pass this filter in most markets.

STEP 04

Hunter.io verifies professional email addresses

Each physician's professional email verified with Hunter.io confidence scoring. LinkedIn profiles matched in parallel. Approximately 89% of physicians have a verifiable professional email.

STEP 05

Multichannel outreach deploys automatically

Saleshandy sends a 4-email sequence on warmed domains. LinkedIn connection plus message fires in parallel. Physical postcard queued to practice address via PostGrid or Lob.

STEP 06

AI prescreens patient referral replies

When a physician replies with a patient, AI checks patient details against study criteria. Qualified patients routed to coordinator with pre-screening summary prepared.

STEP 07

Qualified patient record written to CTMS

Qualifying referrals create a patient record in the CTMS via API. Referral source, referring physician, pre-screening status, and contact all logged automatically.